Rational design of phenyl 2,4,5-trichlorobenzenesulfonate based thiosemicarbazones as α-glucosidase and α-amylase inhibitors: integrating enzymatic evaluation and molecular modeling

RSC Advances 2026 Open access

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Authors: Faiqa Noreen, Magdi E. A. Zaki, Nastaran Sadeghian, Feyzi Sinan Tokalı, Parham Taslımı, Rima D. Alharthy, Halil Şenol, Xianliang Zhao, Furkan Çakır, Sobhi M. Gomha, Zahid Shafiq
DOI: 10.1039/d5ra08761a
Cited by: 6
References: 66

Abstract

findings highlight compound 16 as a promising lead candidate for further optimization and development as a dual α-Glu and α-Amy inhibitor for the management of type 2 diabetes mellitus.

Fields of Study & Subjects

Natural Antidiabetic Agents Studies Enzyme Production and Characterization Carbohydrate Chemistry and Synthesis

Publication details

Journal / source
RSC Advances
Publisher
Royal Society of Chemistry (RSC)
Volume
16
Issue
2
Pages
1662–1681
Publication date
1 January 2026
Language
EN