Construction of a nanozyme composite drug delivery system based on columbianadin for inflammatory bowel disease therapy

RSC Advances 2026 Open access

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Authors: Yanping Zhang, Hong Xi, Dongyuan Qin, Ping Cao, Shuo Yang, Jing Yin, Tianliang Li, Lili Ding
DOI: 10.1039/d5ra08772d
Cited by: 3
References: 26

Abstract

) through a superoxide dismutase (SOD)-catalase (CAT) cascade reaction, thereby alleviating oxidative stress and mitigating hypoxia in the inflamed tissues. In a dextran sulfate sodium (DSS)-induced IBD model, MCG treatment significantly reduced disease activity, restored colon length, preserved mucosal integrity, and suppressed pro-inflammatory pathways. Transcriptomic analysis revealed that MCG reversed IBD-associated gene expression dysregulation and modulated immune-related pathways. The system demonstrated high biocompatibility and effective targeting, providing a synergistic therapeutic strategy for IBD through antioxidative and anti-inflammatory mechanisms.

Fields of Study & Subjects

Advanced Nanomaterials in Catalysis MXene and MAX Phase Materials Nanoplatforms for cancer theranostics

Publication details

Journal / source
RSC Advances
Publisher
Royal Society of Chemistry (RSC)
Volume
16
Issue
5
Pages
4640–4654
Publication date
1 January 2026
Language
EN