Fabrication of methotrexate conjugated multi-walled carbon nanotubes for the evaluation of cytotoxic potential at biochemical and molecular level modulating BAX , BCL-2 and telomerase expression

RSC Advances 2026 Open access

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Authors: Harshita Tiwari, Swati Singh, Vandana Kumari, Shikha Tripathi, Anurag Kumar Singh, Avanish Singh Parmar, Santosh Kumar Singh, Vidhi Gautam
DOI: 10.1039/d5ra08838k
Cited by: 3
References: 61

Abstract

, and reduced telomerase protein expression. Lastly, the alteration in nuclear morphology in all three cancer cells post treatment with MTX-MWCNTs was evaluated through 4',6-diamidino-2-phenylindole (DAPI) staining followed by fluorescence microscopy. Collectively, the obtained findings highlight that MTX-MWCNT efficiently induces apoptosis and inhibits angiogenesis while maintaining significant biosafety, establishing it as an emerging nanoscale platform for targeted cancer therapy.

Fields of Study & Subjects

Nanoparticles: synthesis and applications Graphene and Nanomaterials Applications Carbon Nanotubes in Composites

Publication details

Journal / source
RSC Advances
Publisher
Royal Society of Chemistry (RSC)
Volume
16
Issue
21
Pages
18679–18696
Publication date
1 January 2026
Language
EN