Microwave-assisted N,S doped carbon quantum dots as fluorescent nanoprobes for vibegron determination: face-centered design optimization, validation, and green chemistry assessment
Abstract
-test, and interval hypothesis testing. Furthermore, spiked human plasma analysis demonstrated recoveries ranging from 96.44% to 104.28% with RSD values below 4%, confirming applicability to biological matrices for therapeutic drug monitoring. Comprehensive green chemistry assessment using AGREE (0.65), CaFRI (80/100), and BAGI (70.0/100) metrics demonstrated favorable environmental sustainability characterized by minimal hazardous reagent consumption, low carbon footprint, reduced waste generation, and excellent practical applicability, providing an environmentally benign analytical tool for routine pharmaceutical quality control and therapeutic drug monitoring applications.
Fields of Study & Subjects
Carbon and Quantum Dots Applications
Analytical chemistry methods development
Pharmacological Effects and Assays
Publication details
- Journal / source
- RSC Advances
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 16
- Issue
- 11
- Pages
- 9371–9387
- Publication date
- 1 January 2026
- Language
- EN