New multitarget antidiabetic potential agents based on sulfaguanidine: design, synthesis, and biological evaluation

RSC Advances 2026 Open access

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Authors: Mohammed Salah Ayoup, Asmaa E. Kassab, Amr Sonousi, Shaimaa E. Eldaly, Jawaher Y. Al Nawah, Hamida Abdel-Hamid, Doaa A. Ghareeb, Samah Ashraf, Manar Ahmed Fouad
DOI: 10.1039/d5ra08959j
Cited by: 3
References: 39

Abstract

inhibitory activity of the synthesized sulfaguanidine derivatives against both enzymes. This study reveals that sulfaguanidine-conjugated pyrazole or oxazole derivatives are prospective multitarget therapeutic candidates that can be employed for the treatment of T2DM, which is characterized by complicated etiologies.

Fields of Study & Subjects

Natural Antidiabetic Agents Studies Carbohydrate Chemistry and Synthesis Enzyme function and inhibition

Publication details

Journal / source
RSC Advances
Publisher
Royal Society of Chemistry (RSC)
Volume
16
Issue
5
Pages
4170–4183
Publication date
1 January 2026
Language
EN