Sarcoglaucone A, a novel sarsolenane-related diterpenoid from the soft coral Sarcophyton glaucum

RSC Advances 2026 Open access

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Authors: Yue-Wen Chuang, Atallah Fouad Ahmed, Hsiao-Ling Chung, Yueh-Wen Liu, Su‐Ying Chien, Yu-Chi Lin, Chia‐Ching Liaw, Yu‐Jen Wu, Jing-Ru Weng, Quoc Vu Pham, Jui-Hsin Su, Jyh‐Horng Sheu
+1 more PJ Sung
DOI: 10.1039/d5ra09073c
Cited by: 0
References: 23

Abstract

, collected off the coast of Taiwan. The absolute configuration of dihydrosarsolenone (1) was determined by single-crystal X-ray difraction (SC-XRD) analysis for the first time in this study. The structure of sarsolenane 2 was established on the basis of spectroscopic analysis and further confirmed by SC-XRD analysis. One aspect of the stereochemistry of the known sarsolenanes 1 (dihydrosarsolenone) and methyl dihydrosarsolenoneate was revised. Sarsolenane 1 was found to exhibit activity in enhancing alkaline phosphatase (ALP) activity in human osteoblast-like cells (MG63).

Fields of Study & Subjects

Marine Sponges and Natural Products Bioactive Natural Diterpenoids Research Microbial Natural Products and Biosynthesis

Publication details

Journal / source
RSC Advances
Volume
16
Issue
10
Pages
9224–9232
Publication date
1 January 2026
Language
EN