Exploration of the aromatic abietane diterpenoid scaffold in the development of ArnT-mediated colistin resistance inhibitors

RSC Advances 2026 Open access

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Authors: Silvia Cammarone, Valentina Pastore, Mariya Ryzhuk, Martina Cristoferi, Arianna Speroni, Francesco Imperi, Davide Corinti, Maria Carmela Bonaccorsi di Patti, Bruno Botta, Deborah Quaglio, Mattia Mori, Fiorentina Ascenzioni
+1 more Francesca Ghirga
DOI: 10.1039/d5ra09142j
Cited by: 1
References: 42

Abstract

A function-oriented synthesis (FOS) strategy guided the development of abietane-based derivatives as novel inhibitors of ArnT (4-amino-4-deoxy- l -arabinose transferase)-mediated colistin resistance in Pseudomonas aeruginosa .

Fields of Study & Subjects

Biological Activity of Diterpenoids and Biflavonoids Plant biochemistry and biosynthesis Natural product bioactivities and synthesis

Publication details

Journal / source
RSC Advances
Publisher
Royal Society of Chemistry (RSC)
Volume
16
Issue
12
Pages
11061–11075
Publication date
1 January 2026
Language
EN