K + /Cu 2+ Co-chelated diastereoselective Friedel–Crafts reaction with chiral N -sulfinyl ketimines for the facile synthesis of chiral bisindoles and their cytotoxicity

RSC Advances 2026 Open access

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Authors: Si Yan, Mengwei Xu, Yan Liu, Ziwei Du, Guangshuai Zhang, Zishu Liu, Jin Xiao, Xiaoqian Guo, Gang Liao, Qing Min, Baocheng Xie, Shuanglin Qin
DOI: 10.1039/d5ra09219a
Cited by: 0
References: 38

Abstract

-sulfinyl ketimines has been developed for the synthesis of chiral bisindoles. The method exhibits broad substrate compatibility and high stereoselectivity. The synthesized bisindoles show significant cytotoxicity against tumor cell lines such as MG63 and HepG2, with Compound 29 demonstrating selective inhibitory effects on osteosarcoma cells. This protocol provides a useful strategy for the efficient construction of chiral bisindoles. The potential of these compounds in cancer therapy was also highlighted.

Fields of Study & Subjects

Asymmetric Synthesis and Catalysis Synthesis of Indole Derivatives Sulfur-Based Synthesis Techniques

Publication details

Journal / source
RSC Advances
Volume
16
Issue
8
Pages
7337–7343
Publication date
1 January 2026
Language
EN