Efficient one-pot quinoline derivative synthesis from acetophenone and allyl alcohols

RSC Advances 2026 Open access

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Authors: Fanjia Zeng, Yusheng Xu, Jiezhuang Fang, Huawu Xu, Yulin Cai, Yixia Hong, Junyan Gao, Qinqiang Zeng, Xianzhe Su
DOI: 10.1039/d5ra09229a
Cited by: 1
References: 14

Abstract

a one-pot process. Our investigations revealed that the structure of the transient directing group, solvent, and reaction temperature collectively govern the reaction pathway, allowing precise control over product selectivity. This approach exhibited broad substrate scope and excellent functional group tolerance. This work not only represented the first application of HOSA as an efficient and versatile catalytic transient directing group in C-H cyclization reactions, but also provided a practical and valuable route for the synthesis of quinoline derivatives.

Fields of Study & Subjects

Multicomponent Synthesis of Heterocycles Synthesis of heterocyclic compounds Synthesis and pharmacology of benzodiazepine derivatives

Publication details

Journal / source
RSC Advances
Publisher
Royal Society of Chemistry (RSC)
Volume
16
Issue
3
Pages
2298–2302
Publication date
1 January 2026
Language
EN