Multimodal investigation of dacomitinib–calf thymus DNA binding interaction: insights from spectroscopy, thermodynamics, and in-silico studies
Abstract
conditions and is not intended to imply a direct role in the established anticancer mechanism of dacomitinib. Beyond characterizing a specific drug-DNA system, these findings highlight general principles governing minor groove recognition by non-classical DNA-binding small molecules and underscore the importance of evaluating potential off-target nucleic acid interactions of targeted therapeutics.
Fields of Study & Subjects
Chronic Myeloid Leukemia Treatments
Metal complexes synthesis and properties
DNA and Nucleic Acid Chemistry
Publication details
- Journal / source
- RSC Advances
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 16
- Issue
- 6
- Pages
- 5437–5454
- Publication date
- 1 January 2026
- Language
- EN