Directing group-assisted C–H functionalization of 2-arylbenzo[ f ]isoquinoline: a robust route to decumbenine B analogues with photophysical applications

RSC Advances 2026 Open access

Read full text
Authors: Sampa Mondal, Sudipta Ghara, Sk Abulkalam Azad, Paritosh Barik, Prasenjit Sen, Nayim Sepay, Prasanta Patra, Subrata Mahanta, Laksmikanta Adak, Shubhankar Samanta
DOI: 10.1039/d5ra09256f
Cited by: 0
References: 40

Abstract

Ru/Pd/Cu-catalyzed C-H functionalization. Theoretical and experimental investigations confirmed that Pd(ii) and Cu(ii) preferentially interact with the isoquinoline precursor to drive halogenation and selenation, respectively, while Ru(ii) effectively catalyzes the hydroxymethylation reaction. The protocol is extended to newly synthesized fluorescent molecules that exhibit aggregation-induced emission (AIE) and toxic compound sensing properties. Consequently, this approach assists us in accessing a diverse array of naturally occurring analogues and facilitates more efficient and effective biological studies with minimal effort.

Fields of Study & Subjects

Catalytic C–H Functionalization Methods Radical Photochemical Reactions Synthesis and pharmacology of benzodiazepine derivatives

Publication details

Journal / source
RSC Advances
Volume
16
Issue
2
Pages
1310–1321
Publication date
1 January 2026
Language
EN