Discovery of thieno[3,2- c ]pyran-based leads for liver, lung and glioma cancer: synthesis, docking-guided optimization and apoptotic profiling

RSC Advances 2026 Open access

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Authors: Abhishek Jauhari, Pooja, Lakshay Taneja, Ajay K. Yadav, Ismail I. Althagafi, Ramendra Pratap, Dharmendra Kumar Yadav
DOI: 10.1039/d5ra09341d
Cited by: 1
References: 49

Abstract

against lung cancer targets, respectively. To further confirm the EGFR inhibition, selected compounds were tested agaist EGFR overexpressed glioma cell line, and good cytotoxicity confirms the proposed pathway. These findings suggest that compounds 5a, 5e and 5n warrant further investigation as lead molecules for the development of targeted therapies for liver, glioma and lung cancers.

Fields of Study & Subjects

Synthesis of heterocyclic compounds Synthesis and biological activity Retinoids in leukemia and cellular processes

Publication details

Journal / source
RSC Advances
Publisher
Royal Society of Chemistry (RSC)
Volume
16
Issue
22
Pages
20330–20339
Publication date
1 January 2026
Language
EN