Synthesis of isoxazoles and their hydrazinolysis to 5-aminopyrazoles: an approach to fluorescent derivatives
Abstract
-pyrazoles was developed using readily available ketones as starting materials and eco-friendly microwave-assisted conditions. All reactions proceeded in high yields, and although some of the obtained heteroamines are commercially available, they are challenging to obtain because they are expensive or require access to equally expensive substrates. A computational study using TD-DFT calculations was conducted to better understand the reaction mechanism of the isoxazole ring-opening reaction with hydrazine in water. Ultimately, the photophysical properties of some fluorescent products were conveniently explored.
Fields of Study & Subjects
Synthesis and Characterization of Pyrroles
Fluorine in Organic Chemistry
Organic and Inorganic Chemical Reactions
Publication details
- Journal / source
- RSC Advances
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 16
- Issue
- 10
- Pages
- 8533–8541
- Publication date
- 1 January 2026
- Language
- EN