Electrochemical resolution of purine metabolite overlap using a synthesis-assisted Fe 2 O 3 -RGO heterointerface
Abstract
, overcomes a significant analytical challenge presented by the overlapping signals of these coexisting purine metabolites. The sensor exhibited a low detection limit of 0.003 µM for UA within a linear range of 0.01 µM to 1.99 µM. Furthermore, the electrode's selectivity was confirmed; common biological interferents, such as ascorbic acid, dopamine, glucose, and urea, did not cause significant signal interference. The method's practical utility was confirmed through the analysis of real urine samples, with results showing high recovery rates and statistical agreement with the standard HPLC method. Additionally, this work provides a sustainable and scalable solution to the persistent challenge of purine metabolite overlap, offering a robust platform for the rapid, low-cost, and decentralised monitoring of metabolic disorders in clinical settings.
Fields of Study & Subjects
Electrochemical sensors and biosensors
Electrocatalysts for Energy Conversion
Advanced biosensing and bioanalysis techniques
Publication details
- Journal / source
- RSC Advances
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 16
- Issue
- 11
- Pages
- 9547–9562
- Publication date
- 1 January 2026
- Language
- EN