Hydrolysis mechanisms for A-series (Novichok) nerve agents at different pH V and computational simulant screening
Abstract
-(1-(diethylamino)ethylidene)-P-methylphosphonamidate as optimal hydrolysis simulants. The experimental hydrolysis results for ADPP strongly agreed with the theoretical predictions, confirming the reliability of the methodology. Overall, this study established a predictive framework to determine the dominant hydrolysis pathways and half-lives of amidinofluorophosphonates, enabling the estimation of hydrolysis properties for potential A-series agents based solely on their molecular formulas.
Fields of Study & Subjects
Pesticide Exposure and Toxicity
Insect Pheromone Research and Control
Free Radicals and Antioxidants
Publication details
- Journal / source
- RSC Advances
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 16
- Issue
- 3
- Pages
- 2597–2609
- Publication date
- 1 January 2026
- Language
- EN