Assisted evaluation of aniline's in silico toxicity using artificial intelligence and its simultaneous determination as a toxic impurity with widely used cardiovascular drugs using a green micellar chromatographic method

RSC Advances 2026 Open access

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Authors: Alaa Ahmed Mostafa, Soad S. Abd El‐Hay, Youstina Mekhail Metias, Mohamed Adel Said, Michael Gamal Fawzy
DOI: 10.1039/d5ra09502f
Cited by: 0
References: 26

Abstract

for APN, AEN, ATN, LSN, SAA, and ANN, respectively, and the results obtained were highly accurate. The greenness of the proposed method was ascertained using the green analytical procedure index: score (0.80), blue applicability grade index: score (0.85), and the Analytical GREEnness calculator. A statistical comparison between the results of our study and the reported method showed no significant difference in precision or accuracy.

Fields of Study & Subjects

Analytical Methods in Pharmaceuticals Analytical Chemistry and Chromatography Forensic Toxicology and Drug Analysis

Publication details

Journal / source
RSC Advances
Volume
16
Issue
11
Pages
9563–9577
Publication date
1 January 2026
Language
EN