Triazole-( p -tolylthio)methyl hybrids via click chemistry: synthesis, molecular docking, and evaluation as promising anticancer candidates

RSC Advances 2026 Open access

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Authors: Tamer El Malah, Ahmed A. El-Rashedy, Randa E. Abdel-Mageid, Aymn E. Rashad, Hanan A. Soliman, Hanem M. Awad, Ahmed H. Shamroukh
DOI: 10.1039/d5ra09528j
Cited by: 3
References: 39

Abstract

A series of novel ( p -tolylthio)methyl-linked 1,2,3-triazole derivatives 10–17 was synthesized via Cu( i )-catalyzed click chemistry and structurally characterized.

Fields of Study & Subjects

Click Chemistry and Applications Sulfur-Based Synthesis Techniques Synthesis and biological activity

Publication details

Journal / source
RSC Advances
Publisher
Royal Society of Chemistry (RSC)
Volume
16
Issue
5
Pages
4287–4298
Publication date
1 January 2026
Language
EN