[BMIM]OAc promoted one-pot synthesis of pyrazolo[4′,3′:5,6]pyrido[2,3- d ]pyrimidin-5-ones and their antimicrobial activity

RSC Advances 2026 Open access

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Authors: Savan S. Bhalodiya, Mehul P. Parmar, Shana Balachandran, Chirag D. Patel, Arijit Nandi, Anwesha Das, Madan Kumar Arumugam, Hitendra M. Patel
DOI: 10.1039/d5ra09581f
Cited by: 1
References: 43

Abstract

> 50 µM), with halogenated analogs (4c, 4e) displaying moderate activity but remaining less toxic than doxorubicin. Molecular docking and dynamics simulations confirmed stable interactions of key compounds (4c, 4e, 4f) with bacterial Tet repressor class D and fungal sterol 14-α demethylase, consistent with experimental data. Overall, this ionic liquid-catalyzed approach provides an efficient route to bioactive heterocycles with promising antimicrobial and anticancer potential.

Fields of Study & Subjects

Multicomponent Synthesis of Heterocycles Synthesis and biological activity Synthesis and Reactivity of Heterocycles

Publication details

Journal / source
RSC Advances
Publisher
Royal Society of Chemistry (RSC)
Volume
16
Issue
1
Pages
488–500
Publication date
1 January 2026
Language
EN