Porphyrin-based zinc metal–organic framework loaded with gallic acid as a novel nanoplatform exhibiting H 2 O 2 -activated reactive oxygen species generation and cytotoxicity in breast cancer cells

RSC Advances 2026 Open access

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Authors: Matheus Sampaio Ibrahim, Shaikha S. AlNeyadi, Hesham El-Maghraby, Stefan Wuttke, Yaser E. Greish
DOI: 10.1039/d5ra09585a
Cited by: 1
References: 46

Abstract

induced approximately a 50% reduction in MCF-7 breast cancer cell viability, with negligible impact on normal cell lines. Collectively, these findings substantiate Zn-TCPP@GA as a potent CDT nanotherapeutic platform, capable of tumor-selective ROS amplification through peroxidase-like catalysis and chemodynamic biochemical modulation mediated by gallic acid.

Fields of Study & Subjects

Metal-Organic Frameworks: Synthesis and Applications Nanoplatforms for cancer theranostics Advanced Nanomaterials in Catalysis

Publication details

Journal / source
RSC Advances
Publisher
Royal Society of Chemistry (RSC)
Volume
16
Issue
13
Pages
11727–11743
Publication date
1 January 2026
Language
EN