Photocrosslinkable Morin-loaded gelatin-g-GMA composite hydrogel for accelerating burn wound healing: in vitro and in vivo assessments

RSC Advances 2026 Open access

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Authors: Amr Negm, Samar A. Salim, Tasneem Abed, Marwa Mosaad Shakweer, Esraa B. Abdelazim, Jong Yeog Son, Yasser A. Elnakady, Mahmoud Elsabahy, Elbadawy A. Kamoun
DOI: 10.1039/d5ra09621a
Cited by: 1
References: 53

Abstract

studies using a THP-1-derived M1 macrophage model, showed that the Morin-loaded hydrogel formulations GH-5, GH-6, and GH-7 demonstrated a potent, concentration-dependent suppression of key M1 inflammatory mediators including nitric oxide (NO), IL-1β, and IL-6. This anti-inflammatory effect was mechanistically linked to the downregulation of critical genes (iNOS, COX-2, and STAT-3) that drive the M1 phenotype. Notably, the hydrogel with the highest Morin concentration (GH-7, 5%) exhibited the most significant reduction in inflammatory outputs, suggesting that the therapeutic efficacy is enhanced by Morin loading onto nanofibers. Collectively, this study provides a foundation for the development of functional hydrogels in regenerative medicine and tissue engineering, particularly in relation to burn therapy and modulating macrophage-driven inflammatory pathologies.

Fields of Study & Subjects

Wound Healing and Treatments Hydrogels: synthesis properties applications Graphene and Nanomaterials Applications

Publication details

Journal / source
RSC Advances
Publisher
Royal Society of Chemistry (RSC)
Volume
16
Issue
6
Pages
5619–5631
Publication date
1 January 2026
Language
EN