Thienopyrimidine scaffolds as promising antimicrobial agents: synthesis, biological evaluation, DFT analysis and molecular docking

RSC Advances 2026 Open access

Read full text
Authors: Mostafa Sayed, Menna A. Naguib, Ahmed A. K. Mohammed, Reda Hassanien, Mahmoud S. Tolba, Mostafa Ahmed
DOI: 10.1039/d5ra09678b
Cited by: 3
References: 58

Abstract

DNA gyrase B revealed strong and diverse protein-ligand interactions, consistent with the biological findings, and highlighted compound 13 as the most promising candidate due to its favorable Vina score and extensive hydrogen-bonding and hydrophobic contacts. Collectively, the combined synthetic, biological, and computational analyses underscore the potential of thienopyrimidine scaffolds as valuable agents for developing new antimicrobial agents.

Fields of Study & Subjects

Synthesis and biological activity Synthesis and Reactivity of Sulfur-Containing Compounds Biochemical and Molecular Research

Publication details

Journal / source
RSC Advances
Publisher
Royal Society of Chemistry (RSC)
Volume
16
Issue
6
Pages
5606–5618
Publication date
1 January 2026
Language
EN