Tetrad or triad? insights from a versatile Fe( ii ) structural and functional model of the 3-histidine 1-carboxylate tetrad in C–C bond cleaving dioxygenase enzymes

RSC Advances 2026 Open access

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Authors: Adam Fadul, Thomas R. Cundari, Jeffery A. Bertke, Santiago Toledo
DOI: 10.1039/d5ra09716a
Cited by: 0
References: 60

Abstract

A functional model for the 3-His-1-carboxylate tetrad in dioxygenases. The Fe( ii ) compound displays versatile oxidative C–C bond cleavage via metal-mediated O 2 activation.

Fields of Study & Subjects

Metal-Catalyzed Oxygenation Mechanisms Oxidative Organic Chemistry Reactions Vanadium and Halogenation Chemistry

Publication details

Journal / source
RSC Advances
Volume
16
Issue
10
Pages
8695–8708
Publication date
1 January 2026
Language
EN