Periodic acid-promoted methylenation of imidazoheteroarenes: a green approach using ethylene glycol as a C1 source

RSC Advances 2026 Open access

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Authors: Marcelo Straesser Franco, Matheus Y. G. Watanabe, Jhefferson S. Guilhermi, Brunno S. Souza, Sumbal Bahar Saba, Jamal Rafique, Antonio Luiz Braga
DOI: 10.1039/d5ra09947a
Cited by: 1
References: 47

Abstract

Periodic acid promotes metal-free methylenation of imidazoheteroarenes using ethylene glycol as a green C1 source. The reaction proceeds in water, delivers yields up to 97%, & is scalable, offering a sustainable approach to bis-heterocycle synthesis.

Fields of Study & Subjects

Catalytic C–H Functionalization Methods Synthesis and Characterization of Pyrroles Synthesis and Reactivity of Heterocycles

Publication details

Journal / source
RSC Advances
Publisher
Royal Society of Chemistry (RSC)
Volume
16
Issue
13
Pages
11937–11943
Publication date
1 January 2026
Language
EN