NMR spectroscopic and computational analysis of E / Z isomerism in imines derived from isatin

RSC Advances 2026 Open access

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Authors: Andrés Gonzalez‐Oñate, Diego Chaparro, Rodolfo Quevedo, Jorge Alí-Torres, Areli Flores‐Gaspar
DOI: 10.1039/d5ra09983h
Cited by: 2
References: 31

Abstract

ratio in solution is shown to depend strongly on stabilization by solvent interactions and substituents attached to the imine nitrogen. Predominant isomer structures are typically stabilized by π-stacking between aromatic rings, highlighting the key role of non-covalent interactions in determining stereochemical products.

Fields of Study & Subjects

Organic Chemistry Cycloaddition Reactions Asymmetric Synthesis and Catalysis Structural and Chemical Analysis of Organic and Inorganic Compounds

Publication details

Journal / source
RSC Advances
Publisher
Royal Society of Chemistry (RSC)
Volume
16
Issue
14
Pages
12238–12245
Publication date
1 January 2026
Language
EN