Folic acid-functionalized mesoporous silica nanoparticles integrating fluorouracil-derived carbon dots and porphyrin for targeted breast cancer chemo-photodynamic therapy
Abstract
= 0.384 for pH 5, 7.4, respectively. The nanoplatform has a selectivity index of 8.44 and a 9-fold increase in cytotoxicity upon light activation for MDA-MB-231 cells. The nanoplatform MSNCDs-FA@TMPyP generated 41.12% early apoptosis, 22.07% late apoptosis, and 5.31% primary necrosis in MDA-MB-231 breast cancer cells upon light activation. This research presents a promising new bifunctional nanocomposite that combines the benefits of targeted chemotherapy and photodynamic therapy, offering a synergistic approach to cancer treatment that could lead to improved outcomes.
Fields of Study & Subjects
Carbon and Quantum Dots Applications
Nanoplatforms for cancer theranostics
Photodynamic Therapy Research Studies
Publication details
- Journal / source
- RSC Advances
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 16
- Issue
- 9
- Pages
- 8300–8321
- Publication date
- 1 January 2026
- Language
- EN