Targeting cell cycle and apoptotic pathways with newly synthesized diselenide-linked imidazolone analogues with strong CDK6-targeting potential

RSC Advances 2026 Open access

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Authors: Marwa Abdel‐Motaal, Saad Shaaban, Samia S. Hawas, Asma M. Elsharif, Marwa Sharaky, Fatema Suliman Alatawi, Mohamed E. Eissa, Arwa Omar Al Khatib, Prof. Hany M. Abd El-Lateef, Medhat Asem, Ahmed A. Al-Karmalawy
DOI: 10.1039/d5ra10063a
Cited by: 3
References: 58

Abstract

< 10 µM), highlighting the broader therapeutic relevance of this scaffold. Collectively, these data position 6g as a compelling multi-target anticancer lead that integrates apoptosis induction, cell-cycle regulation, and angiogenesis suppression-supporting its potential for development as a next-generation broad-spectrum anticancer agent.

Fields of Study & Subjects

Cancer-related Molecular Pathways Synthesis of heterocyclic compounds Synthesis of Organic Compounds

Publication details

Journal / source
RSC Advances
Publisher
Royal Society of Chemistry (RSC)
Volume
16
Issue
8
Pages
7066–7079
Publication date
1 January 2026
Language
EN