Multiphysics insights into flow-assisted electrochemical sensing of niclosamide: effects of surface fouling and regeneration

RSC Advances 2026 Open access

Read full text
Authors: Mohamed Abu Shuheil, Abdalkareem Jasim, Subbulakshmi Ganesan, Subhashree Ray, Noor Mazin Basheer, Karthikeyan Jayabalan, Atreyi Pramanik, Apurav Gautam, Amirali Nikpendar
DOI: 10.1039/d5ra10070d
Cited by: 2
References: 38

Abstract

. Long-term simulations over a 30 day operation period predict progressive surface fouling, with the fractional surface coverage rising to 0.78 and the normalized current decaying to 22% of its initial value. A systematic evaluation of regeneration strategies demonstrates that electrochemical voltage pulsing restores up to 95% of the original signal, outperforming solvent washing and ultrasonic cleaning. The proposed model shows excellent agreement with experimental data, yielding a root mean square error of 0.069. Overall, this study develops a quantitative multiphysics modeling framework to analyze the coupled roles of hydrodynamics, electrochemical kinetics, and surface fouling in flow-assisted niclosamide sensing.

Fields of Study & Subjects

Analytical Chemistry and Sensors Electrochemical Analysis and Applications Electrochemical sensors and biosensors

Publication details

Journal / source
RSC Advances
Publisher
Royal Society of Chemistry (RSC)
Volume
16
Issue
15
Pages
13785–13800
Publication date
1 January 2026
Language
EN