Efficient synthesis of ortho - or para -aminophenol via a diazo coupling reduction process and scalable manufacturing of chlorzoxazone

Reaction Chemistry & Engineering 2026

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Authors: Shiyun Li, Wenxin Chen, Ao Chen, Jun Huang, Bin Wen, Xingquan Chen, Xiaojun Bao
DOI: 10.1039/d5re00503e
Cited by: 0
References: 30

Abstract

An efficient and practical diazo-coupling reduction process was established for the synthesis of aminophenols and enabled kilogram-scale manufacturing of the muscle relaxant chlorzoxazone.

Fields of Study & Subjects

Cyclopropane Reaction Mechanisms Chemistry and Chemical Engineering Synthesis and pharmacology of benzodiazepine derivatives

Publication details

Journal / source
Reaction Chemistry & Engineering
Volume
11
Issue
6
Pages
1316–1324
Publication date
1 January 2026
Language
EN