Amino acid appended supramolecular self-associating amphiphiles demonstrate dual activity against both MRSA and ovarian cancer

Chemical Science 2026 Open access

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Authors: Precious I. A. Popoola, Thomas Laurie Allam, Rebecca J. Lilley, Chandni Manwani, Olivia Keers, Junyang Tan, Kylie Yang, Yifan Long, Ewan R. Clark, Lisa J. White, Kira L. F. Hilton, Jennifer Rankin
+12 more Jennifer Baker, Charlotte Bennett, Hollie Wilson, Evelyn R. Morton, Alvaro Keskküla, Bethany K Martin, Christopher O'Connor, J. Mark Sutton, Charlotte K. Hind, Michelle D. Garrett, Cally J. E. Haynes, Jennifer R. Hiscock
DOI: 10.1039/d5sc03376d
Cited by: 2
References: 69

Abstract

Novel amphiphiles target cell membranes, demonstrating biological efficacy against resistant S. aureus and ovarian cancer, with strong mechanistic and DMPK evidence for future therapeutic development.

Fields of Study & Subjects

Supramolecular Self-Assembly in Materials Lipid Membrane Structure and Behavior Surfactants and Colloidal Systems

Publication details

Journal / source
Chemical Science
Publisher
Royal Society of Chemistry (RSC)
Volume
17
Issue
17
Pages
8567–8579
Publication date
1 January 2026
Language
EN