Novel chemistry and structural perspectives in vitamin B 12 -dependent radical SAM enzymes

Chemical Science 2026 Open access

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Authors: Olivier Berteau, Magda Teixeira Nunes, Nicole Taraglio, Pierre Legrand, Alhosna Benjdia
DOI: 10.1039/d5sc04531b
Cited by: 5
References: 184

Abstract

This review highlights the structural and mechanistic diversity of B 12 -dependent radical SAM enzymes and their evolutionary links to other B 12 -dependent enzymes.

Fields of Study & Subjects

Metalloenzymes and iron-sulfur proteins Porphyrin Metabolism and Disorders Neurological diseases and metabolism

Publication details

Journal / source
Chemical Science
Publisher
Royal Society of Chemistry (RSC)
Volume
17
Issue
12
Pages
5840–5856
Publication date
1 January 2026
Language
EN