Identification of Au-hydrides as key intermediates in the reduction of Au( iii ) prodrugs to active Au( i ) species under protic conditions
Abstract
Au III anticancer complexes undergo intracellular reduction to the active Au I species. Here, we identify Au hydrides as important intermediates, and demonstrate the importance of reductive elimination reactions as well as polymetallic Au clusters.
Fields of Study & Subjects
Nanocluster Synthesis and Applications
Metal complexes synthesis and properties
Click Chemistry and Applications
Publication details
- Journal / source
- Chemical Science
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 17
- Issue
- 8
- Pages
- 4183–4190
- Publication date
- 1 January 2026
- Language
- EN