Navigating the next frontier in biomedicine: breakthroughs and insights in nucleic acid therapeutics
Abstract
-acetylgalactosamine (GalNAc) conjugation, and lipid nanoparticles, which collectively enhance stability, target specificity, and clinical applicability. Finally, we discuss persistent challenges such as immune activation, large-scale manufacturing, and long-term safety, and provide perspectives on future directions involving CRISPR-based gene editing, synthetic biology, nanotechnology, smart delivery systems, and combination therapies, aiming to offer strategic insights for the development and clinical translation of nucleic acid drugs.
Fields of Study & Subjects
RNA Interference and Gene Delivery
CRISPR and Genetic Engineering
Pluripotent Stem Cells Research
Publication details
- Journal / source
- Chemical Science
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 17
- Issue
- 7
- Pages
- 3377–3409
- Publication date
- 1 January 2026
- Language
- EN