Visible-light-mediated synthesis of 2-oxetanes via Giese addition to α-oxy radicals
Abstract
Oxetanes have recently garnered large amounts of interest from synthetic chemists due to their unique structural and chemical properties. Despite substantial advances for the formation of 3,3-disubstituted oxetanes, its 2-functionalized counterparts remain a challenging synthetic motif. Furthermore, methods to form alkyl oxetanes remain underdeveloped. Herein, we disclose a novel protocol for the synthesis of various alkyl and aryl 2-oxetanes leveraging a Giese addition to α-oxy radicals, furnishing the desired products in up to 95% yield.
Fields of Study & Subjects
Radical Photochemical Reactions
Synthesis and Catalytic Reactions
Sulfur-Based Synthesis Techniques
Publication details
- Journal / source
- Chemical Science
- Publisher
- Royal Society of Chemistry (RSC)
- Volume
- 17
- Issue
- 13
- Pages
- 6507–6512
- Publication date
- 1 January 2026
- Language
- EN