Spatiotemporally regulated mitochondrial genome editing via enzyme and NIR-activated CRISPR/Cas9 nanoplatform

Chemical Science 2026 Open access

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Authors: Fei Yang, Qianqin Ran, Jiahui Chen, Guochen Bao, Yuezhong Xian, Cuiling Zhang
DOI: 10.1039/d5sc07976d
Cited by: 1
References: 58

Abstract

A dual-responsive CRISPR/Cas nanoplatform enables AND-gated, spatiotemporally controlled mitochondrial DNA editing in tumor cells via activation by endogenous APE-1 and near-infrared light, leading to mitochondrial dysfunction and tumor suppression.

Fields of Study & Subjects

Mitochondrial Function and Pathology CRISPR and Genetic Engineering Cancer Research and Treatments

Publication details

Journal / source
Chemical Science
Publisher
Royal Society of Chemistry (RSC)
Volume
17
Issue
11
Pages
5474–5481
Publication date
1 January 2026
Language
EN