Computational redesign and directed evolution of a lanthanide-dependent photoredox enzyme for enantioselective diol cleavage

Chemical Science 2026 Open access

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Authors: Florian Leiss-Maier, Joshua Behringer, Ghulam Mustafa, Anna Heider, Rahel Mühlhofer, Andreas Sebastian Sebastian Klein, M. Groll, Cathleen Zeymer
DOI: 10.1039/d5sc08010j
Cited by: 2
References: 55

Abstract

A combined approach of AI-guided protein redesign and directed evolution yields enantioselective PhotoLanZymes for cerium-dependent photocatalytic C–C bond cleavage.

Fields of Study & Subjects

Metalloenzymes and iron-sulfur proteins Radical Photochemical Reactions Metal-Catalyzed Oxygenation Mechanisms

Publication details

Journal / source
Chemical Science
Publisher
Royal Society of Chemistry (RSC)
Volume
17
Issue
19
Pages
9552–9561
Publication date
1 January 2026
Language
EN