A general aqueous synthetic strategy towards 1-benzylTHIQs enabled by umpolung hydrazone

Chemical Science 2026 Open access

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Authors: Manpreet Kaur, E. C. Chen, Jan Michael Salgado, Ruofei Cheng, Chao-Jun Li
DOI: 10.1039/d5sc08310a
Cited by: 1
References: 32

Abstract

O are produced as by-products, which minimizes waste generation. A diverse array of substituted 1-benzylTHIQs was synthesized, showing good functional group tolerance (without the need to protect the functional groups) and resulting in moderate to excellent yields. The sustainability of our method was further demonstrated through the synthesis of natural 1-benzylTHIQ based alkaloids and late-stage functionalization of pharmacologically relevant molecules.

Fields of Study & Subjects

Synthesis and Biological Activity Chemical synthesis and alkaloids Berberine and alkaloids research

Publication details

Journal / source
Chemical Science
Publisher
Royal Society of Chemistry (RSC)
Volume
17
Issue
9
Pages
4765–4770
Publication date
1 January 2026
Language
EN