Expanding the chemical space of peptides via biocompatible tryptophan C7-arylation

Chemical Science 2026 Open access

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Authors: Lei Liu, Yanyang Zhao, Yiming Su, Boning Wang, Yue Xiong, Tianhang Wang, Xiude Hua, Yonghao Ye, Zhuangzhi Shi, Huan Wang
DOI: 10.1039/d5sc08312e
Cited by: 2
References: 52

Abstract

, achieving up to 49-fold improvement over the parent peptide. By enabling this biocompatible tryptophan C7-arylation, this work establishes a versatile platform for peptide diversification and therapeutic peptide engineering.

Fields of Study & Subjects

Click Chemistry and Applications Chemical Synthesis and Analysis Supramolecular Self-Assembly in Materials

Publication details

Journal / source
Chemical Science
Publisher
Royal Society of Chemistry (RSC)
Volume
17
Issue
10
Pages
5240–5248
Publication date
1 January 2026
Language
EN