Near-infrared chemiluminescent probe for real-time monitoring of nitroreductase in tumors

Chemical Science 2026 Open access

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Authors: Pan Zhu, Yu Tang, Yuanyu Tang, Shaojing Zhao, Fei Long, Chaoyi Yao, Benhua Wang, Xiangzhi Song, Yi Zhang, Chaochao Tan, Minhuan Lan
DOI: 10.1039/d5sc08342g
Cited by: 5
References: 30

Abstract

and was successfully employed in imaging of NTRase in 4T1 tumor-bearing mice. The findings demonstrate the potential of the NTR-TCN-CL probe in real-time assessment of tumor-associated NTRase activity in the tumor microenvironment and highlight its utilizability as a noninvasive tool for monitoring of the hypoxia-related biomarker.

Fields of Study & Subjects

Molecular Sensors and Ion Detection Nanoplatforms for cancer theranostics Sulfur Compounds in Biology

Publication details

Journal / source
Chemical Science
Publisher
Royal Society of Chemistry (RSC)
Volume
17
Issue
10
Pages
5056–5062
Publication date
1 January 2026
Language
EN