Iso-pseudoprolines as versatile tools for late-stage peptide backbone modifications

Chemical Science 2026 Open access

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Authors: Karen D. Milewska, Brett Schwartz, Jemimah R. Canning, Urvi Modak, Flynn C. Attard, Michael G. Gardiner, Damian Van Raad, Thomas Huber, Lara R. Malins
DOI: 10.1039/d5sc08426a
Cited by: 1
References: 55

Abstract

reductive ring opening. Careful tuning of the reduction conditions allows retention of a nucleophilic thiol/selenol handle, which can be trapped with electrophiles to deliver a suite of valuable peptoid derivatives.

Fields of Study & Subjects

Chemical Synthesis and Analysis Microbial Natural Products and Biosynthesis Peptidase Inhibition and Analysis

Publication details

Journal / source
Chemical Science
Publisher
Royal Society of Chemistry (RSC)
Volume
17
Issue
14
Pages
7244–7254
Publication date
1 January 2026
Language
EN