Machine learning-assisted screening of small-molecule drugs for suppressing protein aggregation and ROS generation based on ECL and CV dual-mode signals amplified by DNA

Chemical Science 2026 Open access

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Authors: Jiaqi Shi, Wenxiu Zhu, Jingyu Yan, Cong Xiao, Huiqin Yao, Lingchen Meng, Hongyun Liu, Lanqun Mao
DOI: 10.1039/d5sc08658b
Cited by: 1
References: 82

Abstract

A machine learning-aided dual-mode electrochemical platform was developed for the screening of small-molecule drugs that can suppress protein aggregation and reactive oxygen species (ROS) generation in neurodegenerative diseases.

Fields of Study & Subjects

Protein Degradation and Inhibitors Computational Drug Discovery Methods Click Chemistry and Applications

Publication details

Journal / source
Chemical Science
Publisher
Royal Society of Chemistry (RSC)
Volume
17
Issue
15
Pages
7560–7574
Publication date
1 January 2026
Language
EN