Pushing the boundaries of BODIPY chemistry: 2-(dimethylamino)methyl BODIPYs as enablers of diversification with nucleophiles

Chemical Science 2026 Open access

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Authors: Sergio Serrano, Carla Marcos, Natalia Casado, Andrea Aranda, Florencio Moreno, Jorge Bañuelos, David Valdivieso González, Iván López‐Montero, Beatriz Lora Maroto, Santiago De la Moya
DOI: 10.1039/d5sc08677a
Cited by: 2
References: 107

Abstract

simple amine quaternization. Importantly, this strategy is compatible with 3,5-dimethylated BODIPYs, preserving access to Knoevenagel-like BODIPY chemistry for large chromophore π-extension towarsds bathochromic shift into the red-to-NIR spectral region. The efficacy of this methodology is demonstrated through the synthesis of a number of BODIPY dyes with diverse substitution patterns and selectable photophysical behavior. Furthermore, we highlight its practical utility through the design of functional BODIPY derivatives, including ICT-based fluorescent pH indicators, fluorogenic acidotropic bioprobes, and water-soluble laser dyes.

Fields of Study & Subjects

Luminescence and Fluorescent Materials Forensic Fingerprint Detection Methods Photochromic and Fluorescence Chemistry

Publication details

Journal / source
Chemical Science
Publisher
Royal Society of Chemistry (RSC)
Volume
17
Issue
14
Pages
7091–7101
Publication date
1 January 2026
Language
EN