AccA from Neisseria gonorrhoeae provides a new framework for understanding periplasmic copper metallochaperones

Chemical Science 2026 Open access

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Authors: Samantha J Firth, William Earl, Denis Thaqi, YoungJin Hong, Charlotte O'Hern, Gemma Luscombe, Dalton H. Y. Ngu, Zhenyao Luo, Chacko Jobichen, Boštjan Kobe, Alastair G. McEwan, Karrera Y. Djoko
DOI: 10.1039/d5sc08738d
Cited by: 0
References: 59

Abstract

cells. Unexpectedly, the Cu(i)-binding affinity of AniA is >50 times weaker than that of AccA, suggesting that Cu delivery occurs against a favourable affinity gradient. We propose that AccA is needed because AniA cannot compete with the periplasmic milieu for binding Cu, providing a new framework to understand why some Cu-dependent enzymes need metallochaperones to deliver Cu.

Fields of Study & Subjects

Trace Elements in Health Metalloenzymes and iron-sulfur proteins Bacterial Genetics and Biotechnology

Publication details

Journal / source
Chemical Science
Volume
17
Issue
18
Pages
9270–9284
Publication date
1 January 2026
Language
EN