Radical docking–migration: a powerful strategy for difunctionalization of alkenes and alkynes

Chemical Science 2026 Open access

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Authors: Zhu Cao, Fushan CHEN, Chen Zhu
DOI: 10.1039/d5sc08771f
Cited by: 16
References: 57

Abstract

radical addition and migration cascades. The scope encompasses various migrating groups, including aryl, heteroaryl, alkynyl, oximino, alkenyl, and imino units, and highlights extensions to challenging unactivated alkenes and alkynes. The mechanistic insights, substrate scope, and synthetic applications of these transformations are discussed, underscoring the potential of the radical docking-migration strategy in modern synthetic chemistry.

Fields of Study & Subjects

Radical Photochemical Reactions Catalytic C–H Functionalization Methods Catalytic Cross-Coupling Reactions

Publication details

Journal / source
Chemical Science
Publisher
Royal Society of Chemistry (RSC)
Volume
17
Issue
6
Pages
2913–2931
Publication date
1 January 2026
Language
EN