From two to one: resolving CO binding in acetyl-CoA synthase

Chemical Science 2026 Open access

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Authors: Denise Poire, Cornelius C. M. Bernitzky, Mathesh Vaithiyanathan, Berta M. Martins, Christian Lorent, Tamanna Manjur Ahamad, Vladimir Pelmenschikov, Igor V. Sazanovich, Gregory M. Greetham, Ingo Zebger, Holger Dobbek, María Andrea Mroginski
+1 more Marius Horch
DOI: 10.1039/d5sc08875e
Cited by: 0
References: 57

Abstract

-CO state. Our results demonstrate that ACS binds a single CO ligand under ambient conditions. This finding clarifies the stoichiometry of CO coordination in ACS and underscores the broader potential of advanced IR spectroscopy, combined with computation, to unravel ligand binding in complex bioorganometallic systems.

Fields of Study & Subjects

Metalloenzymes and iron-sulfur proteins Organometallic Complex Synthesis and Catalysis Metal-Catalyzed Oxygenation Mechanisms

Publication details

Journal / source
Chemical Science
Volume
17
Issue
13
Pages
6755–6765
Publication date
1 January 2026
Language
EN