Ligand assisted Co( ii ) catalyzed direct C–H alkylation of aryl ketones with diverse alkyl halides
Abstract
C NMR and computational studies reveal an unusual fluorenyl-ring slippage, enabling facile C-H alkylation of aryl ketones. The kinetic isotopic study and HRMS analysis confirm the catalytic pathway. This effort represents a significant advancement toward sustainable and economically viable catalytic methodologies for direct C-H alkylation of aryl ketones, potentially opening up new avenues in organic synthesis and industrial applications.
Fields of Study & Subjects
Catalytic C–H Functionalization Methods
Asymmetric Hydrogenation and Catalysis
Catalytic Cross-Coupling Reactions
Publication details
- Journal / source
- Chemical Science
- Publisher
- Royal Society of Chemistry (RSC)
- Publication date
- 1 January 2026
- Language
- EN