Mitochondria-targeting cyclometallated rhodium( iii ) complexes appended with two rhodamine units as Type I photosensitisers for bioimaging and photocytotoxicity applications by inducing pyroptosis

Chemical Science 2026 Open access

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Authors: Katherine Gui-Min Jiang, Guang‐Xi Xu, Lawrence Cho‐Cheung Lee, Fangfang Wei, Siye Wu, Keith Man-Chung Wong, Kenneth Kam-Wing Lo
DOI: 10.1039/d5sc09339b
Cited by: 1
References: 61

Abstract

Cyclometallated rhodium( iii ) dirhodamine complexes targeted mitochondria and, upon photoirradiation, generated reactive oxygen species mainly via the Type I pathway, inducing gasdermin D-mediated pyroptosis through mitochondrial dysfunction.

Fields of Study & Subjects

Inflammasome and immune disorders Heme Oxygenase-1 and Carbon Monoxide Photodynamic Therapy Research Studies

Publication details

Journal / source
Chemical Science
Publisher
Royal Society of Chemistry (RSC)
Volume
17
Issue
16
Pages
8197–8207
Publication date
1 January 2026
Language
EN