Copper-catalyzed enantioselective interrupted azide–alkyne cycloaddition to access axially chiral diaryl ethers

Chemical Science 2026 Open access

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Authors: Ruixue Wu, Lan Chen, Yihan Chen, Qimin Wu, Qirui Chen, Aijun Lin, Hequan Yao, Qiuyu Li, Shang Gao
DOI: 10.1039/d5sc09566b
Cited by: 6
References: 95

Abstract

Bu is essential for the inhibition of protonated byproducts. The orthogonal reactivity of the residual terminal alkyne and amine groups within the products provides versatile platforms for downstream chemistry, enriching the structural diversity of axially chiral diaryl ethers.

Fields of Study & Subjects

Click Chemistry and Applications Cyclopropane Reaction Mechanisms Axial and Atropisomeric Chirality Synthesis

Publication details

Journal / source
Chemical Science
Publisher
Royal Society of Chemistry (RSC)
Volume
17
Issue
23
Pages
11591–11599
Publication date
1 January 2026
Language
EN