From alkynes to spiroindole δ-lactams via a copper-nitrenoid intermediate featuring unusual 1,1-addition and high Z -selectivity

Chemical Science 2026 Open access

Read full text
Authors: Zhiqiang Ren, Tianhui Feng, Yeyao Li, Mengyi Chu, Ye Zheng, Tianli Gao, Bo Han, Ruili Guo, Haojie Ma, Ji‐Jiang Wang, Yuqi Zhang
DOI: 10.1039/d5sc09742h
Cited by: 3
References: 61

Abstract

NHC-copper-catalyzed strategy has been developed for the synthesis of spiroindole δ-lactams from dioxazolones and alkyne derivatives. The methodology offers high atom economy, excellent yields, broad functional group tolerance, and Z -selectivity.

Fields of Study & Subjects

N-Heterocyclic Carbenes in Organic and Inorganic Chemistry Cyclopropane Reaction Mechanisms Catalytic C–H Functionalization Methods

Publication details

Journal / source
Chemical Science
Publisher
Royal Society of Chemistry (RSC)
Volume
17
Issue
19
Pages
9695–9702
Publication date
1 January 2026
Language
EN