An increased throughput workflow to identify ion transport and membrane lysis agents for antimicrobial discovery

Chemical Science 2026 Open access

Read full text
Authors: Kylie Yang, Caleb Marsh, Lisa J. White, Fergus W Molyneux, Thomas Laurie Allam, Precious I. A. Popoola, Olivia Keers, Matthew Rice, Kira L. F. Hilton, Hiral A. Kotak, J. Mark Sutton, Jose Luis L. Ortega-Roldan
+3 more Charlotte K. Hind, Jennifer R. Hiscock, Cally J. E. Haynes
DOI: 10.1039/d5sc09781a
Cited by: 1
References: 74

Abstract

strains, highlighting the promise of our Workflow in identifying potential antimicrobial agents. We then applied our Workflow to investigate the ion transport and lysis properties of a second library (Library 2) of SSAs with established antimicrobial and anticancer properties, aiming to provide insight into the biological modes of action.

Fields of Study & Subjects

Molecular Sensors and Ion Detection Antimicrobial agents and applications ATP Synthase and ATPases Research

Publication details

Journal / source
Chemical Science
Publisher
Royal Society of Chemistry (RSC)
Volume
17
Issue
17
Pages
8580–8594
Publication date
1 January 2026
Language
EN