Asymmetric synthesis of planar-chiral metacyclophanes via aromatic amination enabled enantioselective desymmetrization

Chemical Science 2026 Open access

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Authors: Changyu Zhou, Jinmiao Zhou, Lele Zhang, Wansen Xie, Huanchao Gu, Hua Liu, Xiaoyu YANG
DOI: 10.1039/d5sc09849a
Cited by: 1
References: 56

Abstract

-substituents, chiral cyclophanes with both planar chirality and C-N axial chirality could be generated in a single step. The planar-chiral metacyclophane products have demonstrated good configurational stability and the potential for diverse derivatizations, which underscored the value of this method.

Fields of Study & Subjects

Synthesis and Properties of Aromatic Compounds Supramolecular Chemistry and Complexes Synthetic Organic Chemistry Methods

Publication details

Journal / source
Chemical Science
Publisher
Royal Society of Chemistry (RSC)
Volume
17
Issue
15
Pages
7582–7589
Publication date
1 January 2026
Language
EN